Alice Lebreton Mansuy
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Interactions between Listeria monocytogenes and its human host, in particular regarding host gene expression regulation

  1. Corre M, Bœhm V, Besic V, Kurowska A, Viry A, Mohammad A, Sénamaud-Beaufort C, Thomas-Chollier M and Lebreton A.‡ 2023. Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection. Nucleic Acids Res. 51(22):12459-12475.

  2. Petit TJP and Lebreton A.‡ 2022. (Review) Adaptations of intracellular bacteria to vacuolar or cytosolic niches. Trends Microbiol. 30(8):736-748.

  3. Peron-Cane C, Fernandez JC, Leblanc J, Wingertsmann L, Gautier A, Desprat N‡ and Lebreton A.‡ 2020. Fluorescent secreted bacterial effectors reveal active intravacuolar proliferation of Listeria monocytogenes in epithelial cells. PLoS Pathogens 16(10):e1009001.

  4. Besic V, Habibolahi F,* Noël B,* Rupp S, Genovesio A and Lebreton A.‡ 2020. Coordination of transcriptional and translational regulations in human cells infected by Listeria monocytogenes. RNA Biology. 17(10):1492-1507.

  5. Pagliuso A, Tham TN, Allemand E, Robertin S, Dupuy B, Bertrand Q, Bécavin C, Koutero M, Najburg V, Nahori M-A, Tangy F, Stavru F, Bessonov S, Dessen A, Muchard C, Lebreton A, Komarova AV and Cossart P. 2019. An RNA-binding protein secreted by a bacterial pathogen modulates RIG-I signaling. Cell Host Microbe 26(6):823-35.

  6. Lebreton A‡ and Cossart P.‡ 2017. (Review) RNA– and protein–mediated control of Listeria monocytogenes virulence gene expression. RNA Biol. 14(5):460-70.

  7. Duval M, Cossart P‡ and Lebreton A.‡ 2017. (Review) Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk. Semin Cell Dev Biol. 65:11-19.

  8. Lebreton A,* Stavru F,* Brisse S and Cossart P. 2016. (Conference proceedings) 1926–2016: 90 years of listeriology. Microbes Infect. 18(12):711-23.

  9. Lebreton A, Stavru F and Cossart P. 2015. (Review) Organelle targeting during bacterial infection: Insights from Listeria. Trends Cell Biol. 5(6):330-338.

  10. Cossart P‡ and Lebreton A.‡ 2014. (Review) A trip in the “New Microbiology” with the bacterial pathogen Listeria monocytogenes. FEBS Lett. 588(15):2437-45.

  11. Lebreton A,* Job V,* Ragon M, Le Monnier A, Dessen A, Cossart P and Bierne H. 2014. Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA. mBio 5(1):e00775-13.

  12. Archambaud C, Sismeiro O, Toedling J, Soubigou G, Bécavin C, Lechat P, Lebreton A, Ciaudo C and Cossart P. 2013. The intestinal microbiota interferes with the microRNA Response upon oral Listeria infection. mBio 4(6):e00707-13.

  13. Bierne H, Travier L, Mahlakõiv T, Tailleux L, Subtil A, Lebreton A, Paliwal A, Gicquel B, Stäheli P, Lecuit M and Cossart P. 2012. Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta. PLoS One 7(6):e39080.

  14. Lebreton A, Cossart P and Bierne H. 2012. (Review) Bacteria tune interferon responses by playing with chromatin. Virulence.

  15. Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï P-J, Regnault B, Nahori M-A, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P and Bierne H. 2011. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science 331(6022):1319-21.

‡ Corresponding authors.
* Equal contribution.

An overview of my research on host chromatin subversion by Listeria monocytogenes and the current projects of my group is available.


Regulation of human gene expression and analysis tools

  1. Corre M and Lebreton A.‡ 2023. (Review) Regulation of cold-inducible RNA-binding protein (CIRBP) in response to cellular stresses. Biochimie 217:3-9.

  2. Bahin M,* Noël BF,* Murigneux V, Bernard C, Bassianelli L, Le Hir H, Lebreton A‡ and Genovesio A.‡ 2019. ALFA: annotation landscape for aligned reads. BMC Genomics 20(250).

  3. Lakisic G, Lebreton A,* Pourpre R,* Wendling O, Libertini E, Radford EJ, Le Guillou M, Champy MF, Wattenhofer-Donzé M, Soubigou G, Ait-Si-Ali S, Feunteun J, Sorg T, Coppée JY, Ferguson-Smith AC, Cossart P and Bierne H. 2016. Role of the BAHD1 chromatin-repressive complex in placental development and regulation of steroid metabolism. PLoS Genet. 12(3):e1005898.

  4. Libertini E, Lebreton A, Lakisic G, Dillies M-A, Beck S, Coppée J-Y, Cossart P and Bierne H. 2015. Overexpression of the heterochromatinization factor BAHD1 in HEK293 cells differentially reshapes the DNA methylome on autosomes and X chromosome. Front Genet. 6:339.


Other research works in microbiology

  1. Poydenot F, Lebreton A, Haiech J and Andreotti B. 2023. At the crossroads of epidemiology and biology: Bridging the gap between SARS-CoV-2 viral strain properties and epidemic wave characteristics. Biochimie 213:54-65.

  2. Chekli Y, Peron-Cane C, Dell’Arciprete D, Allemand J-F, Li C, Ghigo J-M, Gautier A, Lebreton A, Desprat N and Beloin C. 2020. Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST. Sci. Rep. 10(1):15791.

  3. Aubry M, Wang W-A, Guyodo Y, Delacou E, Guignier JM, Espéli O, Lebreton A, Guyot F and Gueroui Z. 2020. Engineering E. coli for magnetic control and the spatial localization of functions. ACS Synth. Biol. 9(11):3030-3041.

  4. De Azevedo Wäsch SI, van der Ploeg JR, Maire T, Lebreton A, Kiener A and Leisinger T. 2002. Transformation of Isopropylamine to L-Alaninol by Pseudomonas sp. Strain KIE171 Involves N-Glutamylated intermediates. Appl Environ Microbiol. 68:2368-75.


Post-doctoral studies — Activity and regulation of the eukaryotic RNA exosome

  1. Gudipati RK, Xu Z, Lebreton A, Séraphin B, Steinmetz LM, Jacquier A and Libri D. 2012. Extensive degradation of RNA precursors by the exosome in wild type cells. Mol Cell 48(3):409-21.

  2. Lebreton A,* Rafal T,* Dziembowski A and Séraphin B. 2008. Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature 456(7224):993-7.

  3. Lebreton A and Séraphin B. 2008. Exosome-mediated quality control: Substrate recruitment and molecular activity. Biochim Biophys Acta. 1779(9):558-65.

* Equal contribution.

A summary of my post-doctoral work on the endonuclease activity of the eukaryotic RNA exosome, and on the the regulation of its nuclear functions by the TRAMP complex, can be found here.


PhD thesis — Dynamics of ribosome biogenesis in S. cerevisiae

  1. Lebreton A, Rousselle J-C, Lenormand P, Namane A, Jacquier A, Fromont-Racine M and Saveanu C. 2008. Large ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Nucleic Acids Res. 36(15):4988-4999.

  2. Pertschy B, Saveanu C, Zisser G, Lebreton A, Tengg M, Jacquier A, Liebminger E, Nobis B, Kappel L, van der Klei I, Högenauer G, Fromont-Racine M and Bergler H. 2007. Cytoplasmic recycling of 60S pre-ribosomal factors depends on the AAA-protein Drg1. Mol Cell Biol. 27(19):6581-92.

  3. Lebreton A. 2006. Dynamique des facteurs pré-ribosomiques au cours de la biogenèse de la grande sous-unité ribosomique chez S. cerevisiae. Thesis manuscript.

  4. Lebreton A, Saveanu C, Decourty L, Jacquier A and Fromont-Racine M. 2006. Nsa2, an unstable, conserved factor required for the maturation of 27SB pre-rRNAs. J Biol Chem. 281(37):27099-108.

  5. Lebreton A, Saveanu C, Decourty L, Rain J-C, Jacquier A and Fromont-Racine M. 2006. A functional network involved in the recycling of nucleo-cytoplasmic pre-60S factors. J Cell Biol. 173(3):349-60.

  6. Saveanu C, Namane A, Gleizes P-E, Lebreton A, Rousselle J-C, Noaillac-Depeyre J, Gas N, Jacquier A and Fromont-Racine M. 2003. Sequencial protein association with nascent 60S ribosomal particles. Mol Cell Biol. 23(13):4449-60.

A summary of my PhD thesis work can be found here.


Broad audience publications

  1. Chronicles in biology in Le Monde (since 2018).

  2. Steyer J-S, Allard N, Jandrok T, Lebreton A, Uzan J-P, Bénéteau A. 2024. Jurassic Park and sciences — Chapter “Can dinosaurs be revived?” Belin. EAN:9782410028768.

  3. Lebreton A. 2020. How do we know what drives us ill? Vu.es d’Ulm.

  4. Lebreton A, Bierne H and Cossart P. 2012. Les multiples stratégies de Listeria. Pour la Science (412):42-9.

  5. Lebreton A. 2009. La mise en évidence du bacille de la peste par Alexandre Yersin, Hong-Kong 1894. bibnum.

  6. Lebreton A. 2004. La génétique et les lois de l’hérédité. Encyclopédie Clartés. 6020:1-22.